Proton Pump Inhibitors

Proton pump inhibitors (PPI) medications are commonly prescribed to individuals with heartburn and acid reflux disease. Drugs included in this class include Nexium (esomeprazole magnesium), Prevacid (lansoprazole), Prilosec (omeprazole), Protonix (pantoprazole), Zegerid (omeprazole/sodium bicarbonate), Dexilant (delansoprazole) and Vimovo (esomeprazole and naproxen). These drugs work by reducing the production of acid by blocking the enzyme in the wall of the stomach that produces acid. This reduction of acid prevents ulcers and allows existing ulcers to heal. Unfortunately, the long-term use of PPIs have been associated with the increased risk of developing chronic kidney disease including acute interstitial nephritis. If you or a loved one has used or is using a PPI, read on for the facts about these drugs and the litigation surrounding it.

Facts about PPIs:

  • The first PPI to enter the market was manufactured by AstraZeneca under the brand name Prilosec (generically known as Omeprazole) and approved by the FDA in 1989. The market for PPIs quickly grew between 1995 and 2010 as Takeda Pharmaceuticals, EISAI, Pfizer and Salix Pharmaceuticals entered with competing brand name products. In 2003, Procter & Gamble introduced the first over the counter PPI in Prilosec OTC. This was followed by Novartis Consumer Health, Inc. launching Prevacid 24 hour in 2009 as an over the counter alternative. Then in 2014, Pfizer launched Nexium 24 hour as an over the counter alternative. In fact, PPI sales have grown astronomically since first introduced.
  • The first PPI to enter the market was manufactured by AstraZeneca under the brand name Prilosec (generically known as Omeprazole) and approved by the FDA in 1989. The market for PPIs quickly grew between 1995 and 2010 as Takeda Pharmaceuticals, EISAI, Pfizer and Salix Pharmaceuticals entered with competing brand name products. In 2003, Procter & Gamble introduced the first over the counter PPI in Prilosec OTC. This was followed by Novartis Consumer Health, Inc. launching Prevacid 24 hour in 2009 as an over the counter alternative. Then in 2014, Pfizer launched Nexium 24 hour as an over the counter alternative. In fact, PPI sales have grown astronomically since first introduced.
  • In August 2011, Public Citizen petitioned the FDA to immediately add Black Box warnings and other safety information concerning several severe risks to the product labels of all PPIs on the market which included the risk for Acute Interstitial Nephritis.
  • On October 31, 2014, the FDA finally accepted part of the 2011 Public Citizen petition and agreed to the addition of information regarding some risks including Acute Interstitial Nephritis.
  • Finally in December 2014, PPI labels were updated to include a warning for Acute Interstitial Nephritis.

If you or a loved one has used or is using a PPI and has suffered from Acute Interstitial Nephritis or chronic kidney disease, or you have lost a loved one for one of these reasons, find out how Johnson Becker, PLLC can help you. Please either call us at our toll free number (800) 279-6386 or fill out our case review form here on our website and submit it for a free consultation.

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